Podocytopenia, parietal epithelial cells and glomerulosclerosis
نویسندگان
چکیده
منابع مشابه
Podocytopenia, parietal epithelial cells and glomerulosclerosis.
An estimated 5–10% of the total population is affected by chronic renal disease, which is considered a major cardio vascular risk factor. Diseases of civilization such as arterial hypertension, obesity, old age and diabetes are the most common prime risk factors for developing focal and segmental glomerulosclerosis (FSGS) and subsequent progressive loss of renal function. Many of the affected p...
متن کاملParietal epithelial cells participate in the formation of sclerotic lesions in focal segmental glomerulosclerosis.
The pathogenesis of the development of sclerotic lesions in focal segmental glomerulosclerosis (FSGS) remains unknown. Here, we selectively tagged podocytes or parietal epithelial cells (PECs) to determine whether PECs contribute to sclerosis. In three distinct models of FSGS (5/6-nephrectomy + DOCA-salt; the murine transgenic chronic Thy1.1 model; or the MWF rat) and in human biopsies, the pri...
متن کاملGlomerular parietal epithelial cells contribute to adult podocyte regeneration in experimental focal segmental glomerulosclerosis
As adult podocytes cannot adequately proliferate following depletion in disease states, there has been interest in the potential role of progenitors in podocyte repair and regeneration. To determine whether parietal epithelial cells (PECs) can serve as adult podocyte progenitors following disease-induced podocyte depletion, PECs were permanently labeled in adult PEC-rtTA/LC1/R26 reporter mice. ...
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Two variants of focal segmental glomerulosclerosis are known to present epithelial hypercellularity in the Bowman's space, namely the collapsing and the cellular types. This epithelial cell proliferation may get features of either pseudocrescent or tubular profiles. Our case of collapsing focal segmental glomerulosclerosis has been ultrastructurally investigated concerning the proliferating epi...
متن کاملThe direction and role of phenotypic transition between podocytes and parietal epithelial cells in focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a podocyte disease. Among the various histologies of FSGS, active epithelial changes, hyperplasia, as typically seen in the collapsing variant, indicates disease progression. Using a podocyte-specific injury model of FSGS carrying a genetic podocyte tag combined with double immunostaining by different sets of podocytes and parietal epithelial cell (P...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2014
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gft511